Triptolide (PG490): Mechanistic Precision and Strategic L...

2025-10-18

This thought-leadership article examines the unique mechanistic actions and strategic research applications of Triptolide (PG490), a potent IL-2/MMP/NF-κB transcription inhibitor. Integrating evidence from cutting-edge studies—including pivotal discoveries in Xenopus laevis embryogenesis—this piece provides translational researchers with a roadmap for leveraging Triptolide in immunology, oncology, and developmental biology. Through critical evaluation of biological rationale, experimental validation, competitive landscape, and translational opportunities, we chart a forward-looking vision for Triptolide’s role in next-generation disease modeling and therapeutic strategies.